MyBioSource.com's MOUSE ANTI HUMAN ALPHA B CRYSTALLIN is a Mouse monoclonal antibody. The MOUSE ANTI HUMAN ALPHA B CRYSTALLIN Antibody was generated using Alpha B Crystallin, CRYAB, Crystallin alpha B, HSPB5, and MFM2 as the antigen. It reacts with Human, and Mouse. This antibody has been shown to work in applications such as: ELISA, and Western Blot.
Description
Mouse anti Human alpha B crystallin, clone 2E8 recognizes the basic (b) form of alpha crystallin, alpha B crystallin, a 20kDa water-soluble major structural protein and member of the heat shock protein family, designated HSPB5, which acts as a molecular chaperone and is believed to play a role in the maintenance of ocular lens transparency/refractive index. Besides the involvement of both alpha A and alpha B crystallin in the prevention of protein precipitation and cataract formation in the eye, alpha crystallins have also been demonstrated in other tissues including the heart, brain, kidney, spleen and thymus. Studies have shown that a mutation in alpha B crystallin is responsible for desmin-related myopathy (DRM) and cataract (Perng et al. ). Alpha B crystallin is also a major component of the astrocytic inclusions known as Rosenthal fibers (RFs), found in Alexander's disease (Iwaki et al. 1989)